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* Indications:
– Examide is indicated for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease.
– Use of Examide has been found to be effective for the treatment of edema associated with chronic renal failure.
– Chronic use of any diuretic in hepatic disease has not been studied in adequate & well-controlled trials.
– Examide is indicated for the treatment of hypertension alone or in combination with other antihypertensive agents.
* Dosage & Administration:
– Examide tablets may be given at any time not in relation to a meal. Special dosage adjustment in the elderly in not necessary
because of the high bioavailability of Examide.
– Essential Hypertension: Torsemide has been shown to lower blood pressure when administered once daily at doses of
5mg to 10mg. The antihypertensive effect is near maximal after 4 to 6 weeks of treatment, but it continue to increase for
up to 12 weeks. If administration of Torsemide is suddenly stopped, blood pressure returns to pretreatment levels over
several days, without overshoot. Torsemide has been administered together with beta-Adrenergic blockers, ACE-inhibitors
and calcium-channel blockers; no special dosage adjustment has been needed.
– Examide initial dose is 5mg once daily. If the 5mg dose does not provide adequate reduction in blood pressure within 4 to 6
weeks, the dose may be increased to 10mg once daily. If the response to 10mg is insufficient, an additional antihypertensive
agent should be added to treatment regimen.
– Congestive Heart Failure: Examide initial dose is 10mg to 20mg once daily. If the diuretic response is inadequate, the dose
should be titrated upward by approximately doubling until the desired diuretic response is obtained. Single doses higher than
200mg have not been adequately studied.
– Chronic Renal Failure: Examide initial dose is 20mg once-daily. If the diuretic response is inadequate, the dose should be
titrated upward by approximately doubling until the desired diuretic response is obtained. Single doses higher than 200mg
have not been adequately studied.
– Hepatic Cirrhosis: Examide initial dose is 5mg or 10mg once-daily, administered together with an aldosterone antagonist or
a potassium-sparing diuretic. If the diuretic response is inadequate, the dose should be titrated upward by approximately
doubling until the desired diuretic response is obtained. Single doses higher than 40mg have not been adequately studied.
* Warnings & precautions: Hepatic coma, pregnancy, nursing mothers, pediatric use, hypokalemia.
* Contraindications:
– Torsemide is contraindicated in patients with known hypersensitivity to Torsemide or to sulfonylurea.
– Torsemide is contraindicated in patients who are anuric.
* Store in a dry place at room temperature (at temperature not exceeding 30 degrees C).
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