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30 depottablets (prolonged-release tablets).
* Composition: Each tablet contains: Felodipine 5mg + Metoprolol succinate 47.5mg corresponding to 50mg Metoprolol tartrate.
* Therapeutic indication:
& Hypertension. Logimax can be used when treatment with beta-blockers or calcium antagonists
& of the dihydropyridine type in monotherapy has not produced an adequate effect.
* Posology and method of administration:
– The dosage is individual. The starting dose is based on experience from earlier treatment with
& beta-receptor blockers or calcium antagonists. The normal dosage is one Logimax prolonged
& release tablet (5+50 mg) per day. If required, the dose may be increased to twice daily
& The prolonged release tablet is given once daily, in the morning. The prolonged release tablet
& may be taken on an empty stomach or together with a light meal with a low fat and carbohydrate
& content.
– Elderly patients: One Logimax prolonged release tablet per day is usually sufficient. If required,
& the dose may be increased to twice daily.
– Children: There is a lack of experience of treatment of children.
* Contraindications:
– Known hypersensitivity to any of the components of the product or to the other dihydropyridines or
& beta-blockers.
– Pregnancy.
– Unstable angina pectoris.
– Degree II and III AV block.
– Patients with unstable uncompensated heart failure (pulmonary oedema, hypoperfusion or hypotension),
& and patients with continuous or intermittent inotropic therapy with beta-receptor agonism.
– Symptomatic bradycardia or hypotension.
– Sick sinus syndrome.
– Cardiogenic shock.
– Severe peripheral vascular disease with threat of gangrene.
– Logimax must not be given to patients with suspected acute myocardial infarction with a heart rate of
& < 45 beats / minute, P-Q interval > 0.24 seconds or systolic blood pressure < 100 mmHg.
* Sepcial warnings and precautions for use:
– Combination treatment with digitalis.
– Logimax can exacerbate the symptoms of peripheral vascular disease, e.g. intermittent claudication.
– Severly impaired renal function (GFR < 30 mL/min).
– Aortic stenosis.
– Impaired hepatic function.
– Heart failure following acute myocardial infarction.
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