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Uses and administration: Clopidogrel bisulfate is an Antiplatelet drug that acts by inhibiting
& adenosine diphosphate-mediated platelet aggregation. It is given prophylactically as an
& alternative to aspirin in patients at risk of thrombotic stroke and in the management of
& intermittent claudication and ischaemic heart disease. It is also used as an adjunct to
& aspirin for the prevention of subacute stent occlusion after intra-coronary stenting.
* Contraindications:
& It should not be administered to patients with haematopoietic disorders such as neutropenia
& or thrombocytopenia or other haemorrhagic disorders associated with a prolonged bleeding
& time, or conditions wiith an increased risk of bleeding such as gastrointestinal ulcers,
& acute cerebral haemorrhage, or severe liver dysfunction. It is contraindicated also with
& breast feeding.
* Special warnings:
– Recent serious injury.
– Blood disorder that may lead to internal bleeding.
– Surgery (including dental) within a period of 2 weeks.
– Kidney or liver disease.
– In patients who have experienced severe chest pain (unstable angina or heart attack),
& Myogrel may be prescribed in combination with acetylsalicylic acid (75-325 mg per day).
& A fixed daily dose of 75-100 mg of acetylsalicylic acid is usually recommended for long-
& term co-administration with Myogrel in those patients. In other circumstances, the use of
& acetylsalicylic acid for prolonged periods needs to be discussed with the doctor.
& An occasional use of acetylsalicylic acid (no more than 100 mg in any 24 hours period)
& should not cause a problem.
* Pregnancy and breast-feeding:
– If the patient is pregnant or if she is a breast-feeding mother, she should tell the doctor
& before taking Myogrel. If she becomes pregnant while taking Myogrel, she should consult
& her doctor straightaway.
* Drivers and machines operators:
& Ability to drive or to operate complicated machinery should not be affected by Myogrel.
* Dosage:
– The usual dose is 75 mg once daily.
– Adults (including the elderly): one 75 mg tablet per day, with or without food regularly
& and at the same time each day.
– Not intended for children or adolescents below the age of 18 years.
– If a dose of Myogrel is forgotten but remembered within 12 hours of the usual time,
& the tablet is taken straightaway and then the next tablet is taken at the normal time.
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