Skeletal Muscle Relaxant.
* Indications:
– Painful muscle spasms in the cervical and lumbar regions and postoperative as in herniated intervertebral disc
or osteoarthritis of the hip.
– Spasticity due to neurological disorders, e.g., multiple sclerosis, degenerative diseases of the spinal cord, myelopathy,
cerebrovascular accidents and cerebral palsy.
* Precautions:
– Renal insufficiency (creatinine clearance < 25 mL/min). – Severly impaired liver function. – Patients who have drive or operate machinery. – Patients suffering from hypotension or who are receiving concurrent antihypertensive drugs. * Dosage: – Relief of painful muscle spasms: 1/2 to 1 tablet 3 times daily. In severe cases an extra dose may be taken at night. – Spasticity due to neurological disorders: The dosage should be adjusted to the needs of the individual patient. The initial daily dose (6 mg) may be increased stepwise to reach 12 or 24 mg daily. Daily dose should not exceed 36 mg (9 tablets) – Experience with tizanidine in children is still limited. * Store between 15-30 degrees C.


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