ARICEPT 5 MG 14 TAB اريسيبت


* Therapeutic indications:
& Aricept tablets are indicated for the symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
* Posology and method of administration:
# Adults / Elderly:
– Treatment is initiated at 5 mg / day (once-a-day dosing). ARICEPT tablets should be taken orally, in the evening, just prior to
& retiring. The 5 mg / day dose should be maintained for at least one month in order to allow the earliest clinical responses to
& treatment to be assessed and to allow steady-state concentrations of donepezil hydrochloride to be achieved. Following
& a one-month clinical assessment of treatment at 5 mg / day, the dose of ARICEPT can be increased to 10 mg / day (once-a-day
& dosing). The maximum recommended daily dose is 10 mg. Doses greater than 10 mg / day have not been studied in clinical trials.
& Upon discontinuation of treatment, a gradual abatement of the beneficial effects of ARICEPT is seen. There is no evidence
& of a rebound effect after abrupt discontinuation of therapy.
# Renal and hepatic impairment:
– A similar dose schedule can be followed for patients with renal impairment, as clearance of donepezil hydrochloride
& is not affected by this condition.
– Due to possible increased exposure in mild to moderate hepatic impairment, dose escalation should be performed according
& to individual tolerability. There are no data for patients with severe hepatic impairment.
# ARICEPT is not recommended for use in children.
* Do not store above 30 degrees C.


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