BRILIQUE 90 MG 56 TAB بريليك 90 مجم 56 قرص



** BRILIQUE™ (Ticagrelor) 90 mg 56 film-coated tablets. Oral use.

** Composition:
Each tablet contains:
Ticagrelor 90 mg

** Therapeutic indications
Brilique, co-administered with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with:
– acute coronary syndromes (ACS) or
– a history of myocardial infarction (MI) and a high risk of developing an atherothrombotic event.
For at least the first 12 months following ACS, it is superior to clopidogrel.

** Pharmacotherapeutic group:
Platelet aggregation inhibitors excluding heparin, ATC code: B01AC24

** Mechanism of action:
– Brilique contains ticagrelor, a member of the chemical class cyclopentyltriazolopyrimidines (CPTP), which is an oral, direct acting, selective and reversibly binding P2Y12 receptor antagonist that prevents ADP- mediated P2Y12 dependent platelet activation and aggregation. Ticagrelor does not prevent ADP binding but when bound to the P2Y12 receptor prevents ADP-induced signal transduction. Since platelets participate in the initiation and/or evolution of thrombotic complications of atherosclerotic disease, inhibition of platelet function has been shown to reduce the risk of CV events such as death, MI or stroke.
– Ticagrelor also increases local endogenous adenosine levels by inhibiting the equilibrative nucleoside transporter-1 (ENT-1).
– Ticagrelor has been documented to augment the following adenosine-induced effects in healthy subjects and in patients with ACS: vasodilation (measured by coronary blood flow increases in healthy volunteers and ACS patients; headache), inhibition of platelet function (in human whole blood in vitro) and dyspnoea. However, a link between the observed increases in adenosine and clinical outcomes (e.g. morbidity-mortality) has not been clearly elucidated.

** Read the package leaflet before use.

** Do not store above 30 degrees C.
Keep out of the reach and sight of children.


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